Infection with the ATCC 25923 strain (CATCC and DATCC) did not alter IL-6 levels, but treatment with multiple doses of insulin increased IL-6 production (7- to 6-fold) in the PeLF from infected diabetic rats (DATCC+i2) compared with that of non-insulin-treated animals (DATCC) (Figure 2D). The gene discussed is INS; the disease is infection.