After Cox regression modeling in our cohort, including both the risk allele for PTPN22 and age at time of LTx, SNP rs2476601 was still an independent risk factor for BOS development (p = 0.004, OR: 2.748, 95% CI: 1.369–5.516, data not shown). This evidence concerns the gene PTPN22 and Buschke-Ollendorff syndrome.