IDH1 and neoplasm: We first classified diffuse glioma patients into four categories: IDH1 mutation (IDH1R132MUT) and ZEB1 wildtype (ZEB1WT), IDH1 wildtype (IDH1WT) and ZEB1WT, IDH1R132MUT and ZEB1del, and IDH1WT and ZEB1del, and examined their association with OS with and without adjustment for age and tumor tissue grade (Supplementary Table 1).