NPPB and type 2 diabetes mellitus: Although the exact mechanisms remain to be fully elucidated, several studies reporting on treatment with these two GLP-1R agonists have consistently demonstrated a reduction in blood pressure in patients with T2DM as well as a reduction in brain natriuretic peptide (BNP) levels (Courrèges et al., 2008; Bergenstal et al., 2010; Sun et al., 2015).