BCL2 and periodontal disorder: Moreover, our results suggested that BJe administration down-regulated expression of the pro-apoptotic protein Bax and up-regulated those of the anti-apoptotic Bcl-2 in gingivomucosal tissue from LPS-injected rats, confirming both the role of apoptosis in the pathogenesis of periodontal disease (Song et al., 2017) and the ability of our extract to modulate the apoptotic machinery.