Moreover, our results suggested that BJe administration down-regulated expression of the pro-apoptotic protein Bax and up-regulated those of the anti-apoptotic Bcl-2 in gingivomucosal tissue from LPS-injected rats, confirming both the role of apoptosis in the pathogenesis of periodontal disease (Song et al., 2017) and the ability of our extract to modulate the apoptotic machinery. The gene discussed is BAX; the disease is periodontal disorder.