HMOX1 and diabetic kidney disease: Several studies have revealed that antioxidants prevent the progression of diabetic nephropathy in rodents.(45,46) HO-1 plays an important role as an antioxidant to prevent progression of diabetic nephropathy in mice.(34,47) Furthermore, the administration of ALA/SFC protects kidney against cisplatin-induced nephrotoxicity in rats.(10) ALA/SFC might prevent renal damage in diabetic nephropathy through the induction of HO-1 expression.