NSAID and gastric acid reducing mitochondrial membrane potential cause mitochondrial permeability transaction and subsequently induce O2•− by liberating cytochrome c from mitochondrial intermembranous space into cytosol.(23) Previous studies indicated that BP injured mitochondria as well as this study.(16,24) Mitochondria vulnerable to oxidative stress and it was reported that degeneration of mitochondria was associated with Alzheimer’s disease and diabetes.(25,26) O2•− induced by mitochondria injury the other mitochondria and amount of O2•− increase subsequently. Here, CYCS is linked to Alzheimer disease.