Chromogranin peptides including secretogranin-1 are located in neuritic plaques of the cortical layer in AD patients.(24) The localization of secretogranin-1 is matched with amyloid plaques in AD transgenic mice brains.(29) Mattsson et al.(30) reported that the secretogranin-1 concentration is significantly decreased in early AD patients, and is one possible reason for the reduction of synapses. Here, CHGB is linked to Alzheimer disease.