Although there is some correlation between the distance between the partner genes and the frequencies (both mTOR-TP53BP1 and LRRC59-FLJ60017 gene fusions have their gene partners located in different chromosomes, while both TRMT11-GRIK2 and CCNH-C5orf30 are located in the same chromosome with distances less than 24 MB), TMEM135 and CCDC67 are only separated by 6 MB, and the TMEM135-CCDC67 fusion is exceeding rare in cancers. The gene discussed is TP53BP1; the disease is cancer.