ESR2 and neoplasm: However, PES1, ERα and ERβ protein levels were significantly correlated with tumor size (P = 0.005, 0.003, 0.007), ETE (P = 0.002, 0.001, 0.003), LNM (P = 0.004, 0.006, 0.003), BRAFV600E mutation (P = 0.008, 0.002, 0.004) and TNM stage (P = 0.002, 0.001, 0.002).