Additionally, they highlighted 40 genes (20 upregulated and 20 downregulated) as being essential for MM, of which four were also found in our study, one gene upregulated - ANGPTL4 - and three with diminished expression - NPR3, TNFRSF19, and FBLN1. The gene ANGPTL4 was also found downregulated in MM-MSC in three previous independent studies32–34. The gene discussed is NPR3; the disease is Miyoshi myopathy.