Analysing the 2,000 genes which separately exhibited the highest positive correlation with MITF, TFE3 or TFEB in the metastatic tumors, showed that whereas TFEB and TFE3 share an overlap of 1,201 correlated genes, MITF correlated genes do not overlap with any TFE3 correlated genes and only with 9 TFEB correlated genes (Fig. 3C). This evidence concerns the gene TFE3 and metastatic neoplasm.