In this context, we observed that while APOE-ε4 OR was similar to that reported for Caucasians (ORARG = 3.14 vs ORCEU = 3.6, http://www.alzgene.org/), its frequency in AD cases was lower (26.9% in ARG vs. 38% in CEU, http://www.alzgene.org/). This evidence concerns the gene APOE and Alzheimer disease.