Notably, we prioritized 10 target genes, CACNA1C, CLU, CSNK2B, GABBR1, GRIN2A, MAPK3, NOTCH4, SRR, TNF, and SYNGAP1, which were differentially expressed between schizophrenia cases and controls, validated in mouse models and MalaCards directly (Fig. 4c, Table 1, Supplementary Table S9). This evidence concerns the gene NOTCH4 and schizophrenia.