CRISP2 and hepatocellular carcinoma: As shown in Figure 4, the expressions of AGR2, CRISP2, IL31RA, LINC01477, RLN3, SOX14, TEDDM1, VWA5B2, and ZNF280A were significantly increased in HCC tissues compared with the normal tissues (P-value <0.05) (Figure 4), which were consistent with the results of differential expression analysis.