A lot of studies indicated that Forkhead box C1 (FoxC1), αB-crystallin, Zinc finger and BTB domain containing 20 (ZBTB20), Dysregulated B-cell translocation gene 1 (BTG1), Homeobox A13b (HOXA13), DEK proto-oncogene (DEK), Ubiquitin-specific protease 7 (USP7), and Acyl-CoA Ligase 4 (ACSL4) played important roles in the occurrence and progression of HCC, and they may serve as novel prognostic factors and therapeutic targets for HCC [8–18]. This evidence concerns the gene ZBTB20 and hepatocellular carcinoma.