CETP and coronary artery disorder: (12) sequenced exons of CETP in 58,469 individuals from 12 case-control studies (18,817 CHD cases and 39,652 control subjects) to identify protein-truncating variants (PTVs). Individuals carrying 1 CETP PTV, of whom there were 60 in the study, had 22.6-mg/dl (0.59-mmol/l) higher HDL-C, 12.2-mg/dl (0.32-mmol/l) lower LDL-C, and 6.3% lower TG. Pooling the associations across the individual studies, including data from non-European studies, the summary association of CETP PTVs with risk of CHD was an OR of 0.70 (95% CI: 0.54 to 0.90).