APMAP and Alzheimer disease: Furthermore, extensive biochemical and immuno-histological analyses revealed a 20±4 % increase of cerebral Aβ1-40 levels (Fig. 2d) associated with a 24±5 % increase of the hippocampal Aβ plaque area in the AD mice lacking APMAP as compared to the control AD mice (Figs. 2e, and f).