TRPC1 and endothelial dysfunction: We used a mouse closed-head mTBI model to determine whether mTBI leads to endothelial dysfunction in the aorta utilizing isometric tension measurements and determined the role of the TRPC1 and TRPC6 channels in the pathogenesis of mTBI-induced aortic endothelial dysfunction using commercially available TRPC1 and TRPC6 knockout mouse strains.