Because of the neurological consequences of microglial activation, researchers have attempted to use CSF1R antagonism to deplete microglia in a variety of models to improve neurological function, including traumatic brain injury [38, 39], brain irradiation [50], myelin-induced catatonia [76], experimental autoimmune encephalomyelitis [40], and Alzheimer’s disease [41]. Here, CSF1R is linked to Alzheimer disease.