LOXL4 and neoplasm: Next, to further explore the effect of LOXL4 on tumor metastasis in vivo, SK-Hep1 overexpressing LOXL4 (LOXL4/SK-Hep1) and control cells (vector/SK-Hep1) were orthotopically inoculated into the left hepatic lobe of mice or injected intravenously into nude mice.