TGFB1 and hepatocellular carcinoma: We found that LOXL4 expression was profoundly induced at mRNA level in multiple HCC cell lines (SMMC-7721, SK-Hep1, Huh7, and Hep3B) upon TGF-β treatment (Fig. 2a), but was profoundly induced at protein level only in Huh7 and Hep3B cells, rather than in SMMC-7721and SK-Hep1 cells, compared to vehicle treatment (Fig. 2c).