Expectedly, we found that GW4869 successfully decreased exosome secretion in both LOXL4-overexpressing and control cells (Fig. 7i) and observed a marked decrease of LOXL4 in recipient HCC cells treated with exosomes derived from LOXL4-overexpressing cells incubated with GW4869 (EXO/LOXL4 + GW4869) (Fig. 7j), further indicating that LOXL4 was horizontally transferred between HCC cells via exosomes. This evidence concerns the gene LOXL4 and hepatocellular carcinoma.