Furthermore, we found that LOXL4 upregulation was significantly correlated with tumor differentiation, vascular invasion, and TNM stage and predicted a poor prognosis, in contrast to a previous study demonstrating that LOXL4 is downregulated in HCC tissues, and the downregulation is correlated with aggressive tumors and a worse clinical outcome [12]. Here, LOXL4 is linked to hepatocellular carcinoma.