A great number of studies have confirmed that LOX family play important roles in liver fibrosis and cirrhosis, and online datamining revealed that LOXL4 expression was significantly increased in cirrhosis tissues, even than that in HCC tissues (Fig. 1a), suggesting that TGF-β-induced LOXL4 plays important roles in multisteps of HCC development, especially in the process of liver fibrosis and cirrhosis. This evidence concerns the gene LOXL4 and hepatocellular carcinoma.