In our study, we did not observe the EMT phenomenon in LOXL4-overexpressing cells (data not shown), suggesting that LOXL4 does not promote tumor metastasis via triggering the EMT process; however, we found that LOXL4 contributed to hydrogen peroxide-mediated activation of the FAK/Src pathway and thereby promoted HCC cell adhesion to extracellular matrix (ECM) components collagen I, collagen IV, and fibronectin. This evidence concerns the gene PTK2 and neoplasm.