To evaluate the function of secreted LOXL4 in HCC cell migration, SK-Hep1 and SMMC-7721, two cell lines with low basal levels of LOXL4, were chosen to undergo Transwell migration assays in the presence of CM derived from LOXL4-overexpressing (CM/LOXL4) and control cells (CM/vector). Here, LOXL4 is linked to hepatocellular carcinoma.