Figure S3. Null distribution of the permuted Sum of Most Deleterious Scores \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$ {D}_{gc}^m $$\end{document}Dgcm for the CADD score in TP53 (p-value = 0.000) well-known breast cancer gene; and SLC1A2 (p-value = 0.195) gene not associated with cancer. The gene discussed is TP53; the disease is breast cancer.