Rs7412 in the APOE gene was associated with Fram_CHD (P = 3.0E-12), total cholesterol (P = 2.9E-37), lipidemia (P = 6.2E-33) and Ideal7 (the American Heart Association’s “Life’s Simple Seven” score, i.e., total number of ideal risk behaviors or metrics for each of the seven) (P = 3.3E-14). This evidence concerns the gene APOE and hyperlipidemia.