Nine of the top 10 differentially mutated genes were enriched in the resistant group and led by TP53 mutations (mutation rate, 95.6% in resistant vs. 13.2% in sensitive patients; Fig. 5c, right panel), echoing data from our pan-cancer analysis (Fig. 4a-b) and previous in vitro and in vivo investigations [28, 29]. This evidence concerns the gene TP53 and cancer.