As for previously less explored TTN mutations, the longest gene in human genome known to carry a large number of variations, our data indicated that perhaps TTN acts as a marker gene of tumors sensitized to chemotherapeutic agents such as vinorelbine (P ~ 0; Fig. 4C) and a potential anti-cancer drug epothilone B (P = 2.5 × 10− 253; Fig. 4c). The gene discussed is TTN; the disease is cancer.