In contrast, pathway models trained with CCLE data successfully identified a few top pathways involving both ERBB2 and EGFR, including “anti-apoptotic action of ErbB2 in breast cancer” (see Additional file 5), “ERBB family signaling”, “mitogenic action of ErbB2 in breast cancer” and “EGFR signalling via small GTPase”. The gene discussed is EGFR; the disease is breast cancer.