Current protein AKI biomarkers; ranging from urinary or plasma neutrophil gelatinase-associated lipocalin, urinary IL-18, to tissue inhibitor of metalloproteinases-2* insulin-like growth factor-binding protein 7, were reported in critical care or cardiac surgery settings to predict RRT or death, with AUROC of 0.6–0.85. Here, IL18 is linked to acute kidney injury.