This signal overlaps with the MYP7 locus [56] which spans 11p13-p15.4 and there is suggestive evidence of linkage in the two-point analyses of a 3’ UTR variant in PAX6. The role of PAX6, long postulated as a potential modifier of myopia risk, remains murky, with evidence both supporting and rejecting its involvement [17, 22, 57–66]. This evidence concerns the gene PAX6 and myopia.