In this study, we examined the impact of the complication of DM and the factors associated with glucose metabolism, including hemoglobin A1c (HbA1c), fasting plasma glucose (FPG), fasting immunoreactive insulin (FIRI), and HOMA-IR, on the recurrence of HCC in patients who received curative treatment for this malignancy. This evidence concerns the gene INS and hepatocellular carcinoma.