BECN1 and B-cell chronic lymphocytic leukemia: B-cell Chronic Lymphocytic Leukaemia (B-CLL)/Small Lymphocytic Lymphoma (SLL): Han et al. showed in 2008 that B-CLL cells resistance to TRAIL (TNF-related, apoptosis-inducing ligand) involved the induction of cytoprotective autophagy and that the inhibition of autophagy genes (Becn-1 and Atg5) sensitized the leukemic cells to the drug [180].