PRKAA1 and chronic myelogenous leukemia, BCR-ABL1 positive: Compounds such as Resveratrol, a natural phytoalexin isolated from grapes) and Acadesine (AICAR, 5-aminoimidazole-4-carboxyamide ribonucleoside, known to activate AMPK) were found to induce autophagic cell death in both sensitive or resistant CML cell lines to Imatinib, through AMPK activation and SQSMT1/p62 upregulation [329,330] and through PKC activation [331], respectively.