Another group reasoned that since the phosphatidyl-inositol-3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signalling pathway is often constitutively activated in DLBCL, treatment with the pan-class I PI3K inhibitor NVP-BKM120 could be beneficial in patients. This evidence concerns the gene PIK3CG and diffuse large B-cell lymphoma.