NAMPT and lymphoid leukemia: In a subset of haematological cell lines, including myeloid leukaemia, lymphoid leukaemia, T cell lymphoma and mantle cell lymphoma, Nahimana et al. first demonstrated in 2009 that the treatment of the different cell lines with APO866 (an inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), a key enzyme in nicotinamide adenine dinucleotide (NAD) biosynthesis) promotes cell death associated to autophagy induction [194].