Correspondingly, double immunofluorescence histochemistry for CXCR2 and the endothelial marker protein von Willebrand factor (vWF) of four stereotactic biopsies from healthy (n = 2) and inflammatory active MS (n = 2) brain tissue revealed an upregulation of CXCR2 protein expression in capillaries of MS plaques (CXCR2-positive vessels in MS: 116/157 [74%] versus control: 24/104 [24%]; p < 0.0001, Fisher’s exact test) in situ (Figure 2). Here, VWF is linked to myeloid sarcoma.