CSF3 and myeloid sarcoma: Yet, there is increasing evidence that polymorphonuclear cells (PMN) and neutrophil-attracting CXC chemokines substantially contribute to MS pathology: In EAE, serum levels of granulocyte colony-stimulating factor (G-CSF) rise after immunization with myelin antigens, and depletion of neutrophils or G-CSF receptor deficiency prior to disease onset result in an ameliorated disease course [7,8,9].