MUC5B and idiopathic interstitial pneumonia: Significant overexpression of the secreted Mucin 5B (Muc5B) protein has been found in IPF lungs (Table 3) and it is hypothesised that excess Muc5B impairs the mucosal host defence; in turn, this may interfere with alveolar repair and leads to the development of idiopathic interstitial pneumonia [148].