EGFR and sarcoma: It has recently been demonstrated that MBG in concentrations which are insufficient to block the pumping mechanism of the Na/K-ATPase initiates pro-fibrotic signaling by binding to the Na/K-ATPase and activating Src (sarcoma; proto-oncogene tyrosine-protein kinase) and EGFR (epidermal growth factor receptor) signaling, resulting in degradation of Fli-1 (negative nuclear regulator of the procollagen-1 gene) in the myocardium and induction of collagen-1 synthesis [36].