As DYRK1A triplication has been linked to degeneration of brain neurons in AD-DS and in Ts65Dn mice (García-Cerro et al., 2017; Wegiel et al., 2008), we tested the possibility that neuronal overexpression of mnb is sufficient to cause neurotoxicity and age-related neurodegeneration using two established assays of neurodegeneration in adult flies (Lenz et al., 2013; McGurk et al., 2015). This evidence concerns the gene DYRK1A and Dravet syndrome.