To investigate the contribution of DYRK1A overexpression in the nervous system to various aspects of DS, we overexpressed minibrain (mnb), the Drosophila ortholog of DYRK1A (Duchon and Herault, 2016), in the Drosophila nervous system and implemented well-established assays in larvae and adult flies (Bykhovskaia and Vasin, 2017; Lenz et al., 2013; McGurk et al., 2015). This evidence concerns the gene DYRK1A and Dravet syndrome.