DYRK1A and Dravet syndrome: DYRK1A/Dyrk1a mRNA and protein expression is increased in DS brain and in the brain of different mouse models of DS (Duchon and Herault, 2016; Garcia-Cerro et al., 2018; Kay et al., 2016; Stringer et al., 2017), whether the gene is triplicated as part of a genomic segment, as in Dp1Yey, Ts65Dn, Ts1Cje and Tc1 mice, or alone as in TgDyrk1a and TgDYRK1A mice (Herault et al., 2017).