Our results also reinforce the conclusion from earlier studies with adult mice overexpressing DYRK1A or Dyrk1a, alone or as part of a chromosomal segment, that triplication of DYRK1A is likely to contribute to motor deficits in DS (Altafaj et al., 2001; Arque et al., 2013; Garcia-Cerro et al., 2018; Martínez de Lagrán et al., 2004; Ortiz-Abalia et al., 2008; Souchet et al., 2014; Watson-Scales et al., 2018). This evidence concerns the gene DYRK1A and Dravet syndrome.