DYRK1A and Alzheimer disease: In the Ts65Dn and Ts1Cje mouse models of DS, Dyrk1a overexpression in the brain intensifies with age (Ahmed et al., 2017; Creau et al., 2016; Stringer et al., 2017; Watson-Scales et al., 2018), and this is associated with AD-DS-like histopathological changes in the aged Ts65Dn brain (García-Cerro et al., 2017; Wiseman et al., 2015).