GPC3 and cancer: Presently, a limited repertoire of cancer antigens for DC loading has been identified to be immunogenically efficient that could elicit an immune response and result in tumor eradication, such as MAGE antigens, gp100, α-fetoprotein (AFP), glypican-3 (GPC-3), Wilms tumor 1, NY-ESO-1, MUC1, and mutated neoantigens [1, 4, 8].