Third, serum Ang-2 levels are also closely related to renal function[26] and significantly increase after acute kidney injuries.[3] It is well known that patients with contrast-induced nephropathy (CIN) after PCI are more likely to have adverse cardiovascular outcomes.[27] Therefore, the occurrence of CIN that lead to the increased Ang-2 levels may partly explain why the post-PCI Ang-2 levels was of more prognostic value for cardiovascular events than the pre-PCI Ang-2 levels. This evidence concerns the gene ANGPT2 and acute kidney injury.