It is known that leptin interacts with pathways in the central nervous system and direct peripheral mechanisms.[63] Moreover, the hyperactive leptin signaling network in central and peripheral system has a substantial effect on various steps in BC development and progression, and it can interact with breast epithelial tumor cells and with the different components within the BC microenvironment.[15,63,64] The higher serum leptin levels can increase the risk of BC. Here, LEP is linked to breast cancer.