Resveratrol, a natural polyphenols has been reported to possess anticancer properties in a wide variety of tumour cell types including breast, prostate, stomach, colon, pancreas and thyroid cancers.20, 21 It can suppress proliferation, invasion and apoptosis by regulating NF‐κB and activator protein‐1 activities.18, 19 One of the resveratrol derivatives TMS was found to be more potent than resveratrol as an anticancer agent.9, 11 In this study, we evaluated the anticancer effects in vitro and in vivo. The gene discussed is NFKB1; the disease is thyroid gland carcinoma.