EGFR and non-small cell lung carcinoma: Trans‐3,5,4′‐trimethoxystilbene (TMS), a polyphenolic compound known by the chemical name of Stilbene, is a synthetic analogues of resveratrol, a constituent of red wine, vegetables and Chinese medicines, Polygonum cuspidatum for example.6 TMS has been reported to possess more potent anticancer and antiangiogenic activities than resveratrol.7, 8, 9, 10 Resveratrol and its derivatives have been found to exert some effects on NSCLC,11 especially on EGFR‐TKI resistance, but the underlying mechanisms remain unclear.