Similarly, cardiac tissue in diabetic animals exhibits increased inflammation, with higher levels of TNF‐α, IL‐6 and IL‐1β, all of which can profoundly alter cardiac function.9, 38, 39 We found that FBXL10 overexpression protected cardiac tissue against inflammation, underscoring the protective role of FBXL10 in the context of cell death associated with DCM. Here, KDM2B is linked to familial dilated cardiomyopathy.