Cell death is a key factor of STZ‐induced cardiomyopathy.39, 40 Previously study reported that FBXL10 regulates cell death as an anti‐apoptotic protein and suppress TRAIL‐induced apoptosis.41 In the current study, we found overexpression of FBXL10 inhibited HG‐induced apoptosis in H9c2 cells and STZ‐induced apoptosis in animal model. Here, TNFSF10 is linked to cardiomyopathy.