KDM2B and diabetes mellitus: Previously study has reported the relationship between FBXL10 and development including heart defects.32 Some studies also found that the expression level of FBXL10 association cell death regulation.33, 34 Importantly, we found that STZ‐treated diabetic rodents presented with both impaired diastolic and systolic cardiac functions, and FBXL10 overexpression improved these functions and reduced diabetes‐associated cardiac injury accordingly.