KDM2B and familial dilated cardiomyopathy: Sharp increases in oxidative stress are thought to be among the key drivers of DCM progression, with elevated ROS production in myocytes in response to HG leading to increased DNA damage, lipid peroxidation, cell death, and consequent cardiac dysfunction.35, 36 Identifying factors that can suppress oxidative stress is thus invaluable.37 We have provided clear evidence that FBXL10 can protect against HG‐induced ROS production in vitro.