NFKB1 and TNF receptor 1-associated periodic fever syndrome: Toll‐like receptor 4 (TLR4) is an important LPS receptor, and TLR4‐mediated mitogen‐activated protein kinase (MAPK) and nuclear factor‐κB (NF‐κB) signaling pathways play important roles in inflammation and FHF (Crispe, 2009; Malhi et al., 2010).