To identify interactions that are reliant upon UBTF-dependent rDNA class switching as opposed to those that are intrinsically a consequence of malignant transformation, we performed 4C-seq in the stable Ubtf knockdown lymphoma cells (Eμ-Myc-shUbtf) compared to control cells (Eμ-Myc-LMP). The gene discussed is UBTF; the disease is lymphoma.