CTNNB1 and colorectal cancer: Aspirin reduced β-catenin expression, which in turn inhibits transcription and activation of MYC, reducing colorectal cancer potential.46 On the other hand, at the same location in CTNNB1 the substitution to a G allele, rather than a T allele, results in increased destruction complex binding and may promote colorectal cancer progression.47 Similar associations of reduced colorectal cancer risk have been observed for the SNPs rs2965667 (TT) in MGST1 and rs16973225 (AA) located near IL16. 47