TP53 and glioblastoma: Finally, of the two miscellaneous HDAC inhibitors, DATS has been shown to cause upregulation of the cell cycle inhibitor p21Waf1/Cip1 and the tumor suppressor p53 in order to cause cell cycle arrest in glioblastoma cells and is unique in that it is derived from garlic and demonstrates less toxicity to normal cells than other HDAC inhibitors[74].