GFAP and neoplasm: Similar to SAHA, TSA also induces differentiation and apoptosis in human glioblastoma cell lines, resulting in a higher expression of astrocytespecific markers [i.e., glial fibrillary acidic protein (GFAP)] and reduced expression of vimentin and nestin (common markers of neuro-epithelial stem cells)[68], increasing the recognizability of the tumor cells to the immune system.