A large, multicenter randomized controlled trial (RCT) assessed the efficacy of omalizumab in 419 subjects (mean age 10.9 years) with persistent allergic asthma, and showed that anti-IgE treatment increases the number of symptoms-free days and reduces the number of exacerbations and the need for controller therapies (16). The gene discussed is IGHE; the disease is allergic asthma.