MTAP and renal cell carcinoma: In a screen of nephrectomy samples from another cohort of 56 patients with RCC, we found that abundant MTAP staining in samples was significantly greater in patients with grade 1 (G1) RCC than in patients with grade 2 (G2) and grade 3 (G3) RCC (Fig. 1c), at a rate of 75% versus 52 and 0%, respectively (Fig. 1d).