MTA is the substrate of methylthioadenosine phosphorylase (MTAP), a catabolic enzyme that rescues adenine and methionine through the catalysis of MTA phosphorylation, which ultimately yields adenine and methylthioribose-1-phosphate.15 As expected, given the role of MTAP in MTA metabolism, significant MTA accumulation has been observed in MTAP-deficient cells, particularly in cancers.16–19. The gene discussed is MTAP; the disease is cancer.