AIF1 and Alzheimer disease: At 24 months of age, 20 months after the onset of CPF exposure, both male and female CPF-exposed TgF344-AD rats exhibited significant reductions in Iba1+ staining in the hippocampus relative to vehicle-exposed TgF344-AD rats, while 20-month-old WT animals of either sex were unaffected by CPF exposure (Fig. 6d, g).