CDKN1B and cancer: EGCG has been found to affect several cancer-related proteins including Cyclin-dependent kinase inhibitor p27 (p27), Bcl-2 or Bcr-Abl oncoproteins, Bax, matrix metalloproteinases (MMP-2 and MMP-9) [26] the androgen receptor, EGF receptor, Activator proteins 1(AP1), and some cell cycle regulators.