Additionally, a significant reduction in the expression of Proliferating Cell Nuclear Antigen (PCNA) proteins was observed in the prostate of GTP-fed animals compared to water-fed TRAMP mice was observed, GTP fed mice also demonstrated significant apoptosis, potentially leading to reduction in dissemination of cancer cells, ultimately inhibiting development, progression and metastasis of PCa to distant organ sites. Here, PCNA is linked to posterior cortical atrophy.