In addition to reduction of serum PSA, McLarty et al. [33], showed a significant reduction in Hepatocyte Growth Factor (HGF), and Vascular Endrothelial Growth Factor (VEGF) after treatment with GTC containing a doe of 800 mgs EGCG (Polyphenon E) targeting PCa patients, with no elevation of liver enzymes. This evidence concerns the gene VEGFA and posterior cortical atrophy.