Likewise, high LOXL2 mRNA expression has been found to associate with lymph node metastasis in esophageal squamous cell carcinoma [86] and with decreased overall survival in lung squamous cell carcinoma and lymph node-negative breast adenocarcinoma [87], and in colon cancer [88]. The gene discussed is LOXL2; the disease is esophageal squamous cell carcinoma.