Comparison between low (n = 59 patients) and high (n = 708 patients) plasma Ang-2 levels demonstrated statistically significant differences between the levels based on the presence of cirrhosis, Child-Pugh score, the presence of vascular invasion and vascular thrombosis, tumor involvement >50% of the liver, multinodularity, alpha-fetoprotein (AFP) levels, HCV positivity, and history of cigarette smoking (Figure 1B). The gene discussed is AFP; the disease is neoplasm.