In contrast, plasma Ang-2 levels were significantly lower in healthy controls (mean = 4.4 ng/ml; 95% CI, 4.2–4.7 ng/ml) than in cirrhotic (mean = 15.2 ng/ml; 95% CI, 12.6–17.8 ng/ml) and in HCC patients (mean = 15.3 ng/ml; 95% CI, 14.1–16.4 ng/ml) (p < 0.001) (Figure 2A). The gene discussed is ANGPT2; the disease is hepatocellular carcinoma.