Plasma Ang-1 levels were significantly lower in cirrhotic patients (mean = 11.6 ng/ml; 95% CI, 10.2–13.0 ng/ml) than in healthy controls (mean = 16.0 ng/ml; 95% CI, 14.9–17.1 ng/ml) and in HCC patients (mean = 16.1 ng/ml; 95% CI, 15.4–16.7 ng/ml) (p < 0.001) (Figure 2A). This evidence concerns the gene ANGPT1 and hepatocellular carcinoma.