SPO11 and cancer: Therefore, we surveyed the expression of meiosis (mRNA and protein levels) and LINE-1 ORFp1 in breast (MCF7, T47D, MDA-MB 231), lung (A549, A427, Calu6, H460, H28, H23, H1975, H1299) prostate (PC3), bladder (DU145), colorectal (HT29 and HCT116) and pancreatic (BxPC3, HPAFII, Panc1, MiaPaCa2) cancer cells and found that the above described machineries are also expressed across a broad spectrum of patient-derived cell lines representing these malignancies (Figure 7, due to space limitations only Western Blot data for SPO11, STRA8 and LINE-1 are shown).