The role of CD14 polymorphisms in autoimmune disorders has been widely explored, including inflammatory bowel disease (IBD) (9–11), multiple sclerosis (MS) (12), rheumatoid arthritis (RA) (13–15), juvenile idiopathic arthritis (16), systemic lupus erythematosus (15), and type 1 diabetes mellitus (T1DM) (17). The gene discussed is CD14; the disease is inflammatory bowel disease.