Besides, if the patient ́s Alberta Stroke Program Early CT Score (ASPECTS)3, which is used for assessing the size of the infarct on brain CT scans , is less than or equal to six, the patient is not eligible to the t-PA administration 1,2,4,5 as there is a high risk of malignant middle cerebral artery infarction after the t-PA administration .6 This evidence concerns the gene PLAT and middle cerebral artery infarction.